Biology of Drug Abuse
When drugs attacks the brain’s communication system ,the normal functioning of the brain cells get disrupted ,which sends , receives and process the information. By imitating the brain neurotransmitters and by over-stimulating the “reward circuit” of the brain , a drug disrupts a normal cell function. Some drugs such as marijuana and heroin which are naturally produced, fool the brain receptors. The Dopaminergic pathway ,which is the most important reward pathway in brain is composed of the VTA (ventral tegumental area) and NAc (nucleus accumbens) is a part of a series of parallel, integrated circuits. This (VTA-NAc) circuit is a key detector of a rewarding stimulus and is an important determinant of motivation and incentive drive. When the pathway get activated it tells the individual to repeat what it just did to get that reward. It is involved in several other key brain regions.
- Track 1-1 NIDA(National Institute on Drug Abuse)
- Track 2-2 Sterotonin-biochemical assay
- Track 3-3 Cognitive differences
- Track 4-4 Neurobiology of reward
- Track 5-5 Dopaminergic pathway