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Patient satisfaction is one of the important indicators in the quality of health care. Iowa Satisfaction with Anesthesia Scale (ISAS) questionnaire is one of the robust questionnaires measuring patient satisfaction in anesthesia care. However, the Persian version of this questionnaire is not available. Therefore, this study examines the validity and reliability of the Persian version of the ISAS questionnaire. This questionnaire has 11 questions (3 questions about pain, 6 questions about patient experiences during the surgery, and 2 questions about satisfaction of patient). Patient pain is one of the most important factors that modulate the patient satisfaction in anesthetic care. Materials and Methods: In this clinical trial, 230 candidates for eye surgery with topical anesthesia entered the study. After obtaining informed consent, the Persian version of the ISAS questionnaire was completed during and one hour after the operation. Reliability, face, content, concurrent and criterion validity was evaluated. Results: The questionnaire was completed for 205 patients. The mean age was 68.26 ± 10.61, including 98 (47.8%) men and 107 (52.2%) women. The average ISAS scores of patients are 1.02± 0.65 and its range was -1.55-2.00. Cronbach's alpha coefficient was 0.71 and there was a positive and significant correlation between test-retest scores. Facial and content validity was approved. In addition, a significant correlation with the satisfaction of the surgeon and visual analog scale (VAS) scores was observed, which suggests concurrent and criterion validity. In this study the satisfaction of pain extensively was considered and compared with VAS. There was significant correlation between the ISAS questionnaire and VAS (r= -0.524, p=0.0001). Conclusion: The findings of this study confirm the validity and reliability of the Persian version of the ISAS in outpatient satisfaction of anesthesia cares. Furthermore, our data suggest that this questionnaire is completely useful for considering the patient satisfaction of anesthesia and pain.