Sadia Mughal
University of Azad Jammu and Kashmir, Pakistan
Title: Prevalence of inherited/congenital neurological disorders in Azad Jammu and Kashmir
Biography:
Sadia did her Ph.D scholar from university of Azad Jammu and Kashmir Pakistan. My Ph.D. thesis is based on molecular genetic studies of Inherited skin and neurological studies in Kashmiri population.I was awarded by a fellowship of Pakistan HEC now Iam working on NGS data analysis since June 2018 at university Mcgill department neurology and neurosurgery Canada.
Abstract:
Large scale epidemiological studies on inherited/congenital neurological diseases are rare in Pakistan and also in Azad Jammu and Kashmir. Therefore, we conducted a population based cross sectional epidemiological study on a stratified randomly selected samples from the four major districts of AJ &K to study the four major inherited/ congenital neurological disorders which includes; intellectual disability, microcephaly, neuromuscular dystrophy and Parkinson’s disease.
Methodology: Families with inherited/congenital neurological disorders were randomly recruited through door to door survey. Approval for this study was obtained by board of advanced studies from University of Azad Jammu and Kashmir.
Findings:
Total 10,000 individuals were selected for interview among which 9711 (97.11%) took part in the study while 289(2.89%) refuse to take part in this study. Among responsive, the total number of affected individuals with different neurological disorders was 466 (4.80%) with an age range of 1-60 years. According to this data prevalence of neurological disorders in males was more 272 (5.67%) than the females 194(3.94%). The highest prevalence was recorded in age <18 years 253 (6.40%). Among the total positive cases intellectual disability was most frequent 337 (72.31%), followed by microcephaly 64 (13.7%), neuromuscular dystrophy 51(10.90%) and Parkinson 14 (3. 00%).
Conclusion & Significance:
Present data suggests that inherited intellectual disability is the most frequent among all neurological disorders so further exploration, population base studies and genetic counseling is necessary.