Liliya Abramova
FSBSI MHRC, Russia
Title: Agomelatine as ameans of effective therapy of anhedonic endogenous depressions
Biography:
Abstract:
Background: Anhedonia determines the specificity of the clinical picture and the severity of state in the structure of endogenous depressions. The aim of the study was to investigate the therapeutic picture of new generation antidepressant with melatoninergetic effect of agomelatine (valdoxane) in anhedonic depressions and to develop personified indications for its use. Material and methods: The study was carried out as an open label prospective with informed consent of patients for participation in it. A total of 30 patients with endogenous depressions. were examined, the clinical picture of which was determined by anhedonic disorders in various spheres of psychic activity; in the sphere of interests, social activity, emotional involvement, eating/drinking (F31.3-4; F32.1-2, and F33.1-2 according to ICD-10). All the patients received course treatment (30 days) with agomelatine (AG) at a daily dose of 25-50 mg. Clinical-psychological, psychometric (HAMD, SHAPS rating scales), and statistical methods were used. AG therapeutic effect was evaluated according to Mean total score (MTS) reduction of the examined parameters. Results: Total AG antidepressive effect made up 78,9% of MTS reduction according to HAMD. Differences in therapeutic AG effect were revealed both with respect to anhedonic component of depression in whole, as well as in the dynamics of its indices according to separate SHAPS spheres. By the end of the study the index in the sphere of interests was high in percent age terms, buti was inferior to in dices of reduction in anhedonia in other spheres: social activity, emotional involvement, making up 88.2% against 91.7; 95.2% correspondingly. Conclusion: The results of the conducted study allow considering the method of AG course treatment as preferable and highly effective in anhedonic endogenous depressions. High therapeutic antianhedonic AG efficacy, rapidity of detection of therapeutic impact in combination with good drug tolerability substantiated the choice of the given method of anhedonic depressions treatment.